After complete elimination of cancerous lesions in patients with advanced liver cancer, Can-Fite files patent applications for the treatment of various advanced solid tumors
Namodenoson Heads For Pivotal Phase III Liver Cancer Study
PETACH TIKVA, Israel, December 29, 2021– (BUSINESS WIRE) – Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI), a biotechnology company developing a pipeline of proprietary small molecule drugs that treat inflammatory, cancer and liver diseases, today announced the company is filing new patent applications in several countries for the treatment of all advanced solid tumors based on new clinical data showing that a patient with advanced hepatocellular carcinoma (HCC), the most common form of liver cancer, has been cleared of all tumor lesions after treatment with Namodenoson, an adenosine A3 receptor (A3AR) ligand. These pending patent applications are the latest in Can-Fite’s growing intellectual property portfolio spanning its platform technology, as well as its drug candidate Namodenoson and its use in a variety of advanced cancers.
Can-Fite’s Namodenoson, a small, orally bioavailable drug that binds with high affinity and selectivity to A3AR, has recently been shown to be effective in clearing all cancerous lesions in a patient treated for an open label extension program of its completed phase II study for the treatment of HCC. In the first quarter of 2022, Can-Fite plans to begin patient enrollment in its pivotal Phase III trial for Namodenoson in the treatment of patients with advanced HCC with underlying Child Pugh B7 cirrhosis (CPB7 ) to support a New Drug Application (NDA) submission and approval.
“Can-Fite’s intellectual property portfolio includes approximately 200 patents and pending patent applications in 16 patent families. Given the very strong new data on the efficacy of Namodenoson in advanced HCC, these latest patent filings aim to further strengthen our intellectual property position regarding Namodenoson in liver cancer and also expand our pending claims for advanced diseases. in other cancer indications, ”said Can-Fite President Dr. Ilan Cohn, Senior Partner and Founder of Cohn De Vries Stadler & Co., a leading intellectual property company.
Namodenoson is a small, orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson has been evaluated in phase II trials for two indications, as a second-line treatment for hepatocellular carcinoma and as a treatment for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A3AR is highly expressed in diseased cells while low expression is found in normal cells. This differential effect explains the excellent safety profile of the drug.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an advanced clinical drug development company with a technology platform designed to address multi-billion dollar markets in the treatment of cancer, liver and inflammatory diseases . The Company’s lead drug candidate, Piclidenoson, is currently in a Phase III trial for psoriasis. Can-Fite’s liver drug Namodenoson is heading into a Phase III trial for hepatocellular carcinoma (HCC), the most common form of liver cancer, and a Phase IIb trial for the treatment of steatohepatitis non-alcoholic (NASH). Namodenoson has received orphan drug designation in the United States and Europe and expedited designation as a second-line treatment for HCC by the United States Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers, including colon, prostate, and melanoma. CF602, the Company’s third drug candidate, has been shown to be effective in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,500 patients in clinical studies to date. For more information, please visit: www.can-fite.com.
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