Liver medicine – Rogalevich http://rogalevich.org/ Thu, 26 May 2022 02:00:45 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://rogalevich.org/wp-content/uploads/2021/10/icon-120x120.png Liver medicine – Rogalevich http://rogalevich.org/ 32 32 Treatment of myelodysplastic syndrome by hyp https://rogalevich.org/treatment-of-myelodysplastic-syndrome-by-hyp/ Thu, 26 May 2022 02:00:45 +0000 https://rogalevich.org/treatment-of-myelodysplastic-syndrome-by-hyp/ Hypomethylating agents (HMAs) are currently used as first-line treatment for patients with myelodysplastic syndrome (MDS), and increasingly in other diseases, but their mechanism of action is unclear. HMAs can affect many genes and could potentially activate an oncogene – a gene that contributes to the development of cancer – but this has not been clearly […]]]>

Hypomethylating agents (HMAs) are currently used as first-line treatment for patients with myelodysplastic syndrome (MDS), and increasingly in other diseases, but their mechanism of action is unclear. HMAs can affect many genes and could potentially activate an oncogene – a gene that contributes to the development of cancer – but this has not been clearly demonstrated to date. To test this, researchers from Brigham and Women’s Hospital, Harvard Stem Cell Institute and collaborators studied how HMA affects known oncogenes. They found that HMA activated the oncofetal protein SALL4 in up to 40% of patients with MDS, resulting in poor patient survival, even in patients in clinical remission. The results may apply to other cancers and diseases in which HMAs are used.

“SALL4 is an embryonic stem cell (ES) gene and a leukemic stem cell factor, and it belongs to a new class of oncofetal gene. Gain-of-function SALL4 transgenic mice develop MDS and acute myeloid leukemia (AML), as well as liver tumors. Loss-of-function studies have demonstrated that SALL4 is essential for the survival of cancer cells, including leukemic cells, by regulating several survival pathways. Our data suggest that patients with MDS receiving HMA treatment should be monitored for demethylation and upregulation of oncogenes such as SALL4, which we believe are linked to poor outcomes, and these patients should receive additional combination therapy. said lead author Li Chai, MD, of Brigham’s Department of Pathology.

The Chai lab has been working on SALL4 since 2003, and Chai has led a research program focused on the function, mechanism, structure, and targeting of SALL4. Given the unique oncofetal expression pattern of the gene, she and her collaborators pioneered a breakthrough SALL4-based approach to classify and target cancer, and their previous work demonstrated the feasibility of targeting this ES cell gene in cancers ( Yong KJ, et al NEJM, 2013, Liu B, et al PNAS, 2018, Yang J, et al Cancer Research, 2021).

Learn more in The New England Journal of Medicine.


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Liver Disease Diagnostics Market 2022 by Key Players and Suppliers Abbott, Horiba Medical, Randox Laboratories, Roche, Fujifilm Corporation, Thermo Fisher Scientific, LabCorp, Boston Scientific Corporation, Siemens Healthcare GmbH https://rogalevich.org/liver-disease-diagnostics-market-2022-by-key-players-and-suppliers-abbott-horiba-medical-randox-laboratories-roche-fujifilm-corporation-thermo-fisher-scientific-labcorp-boston-scientific-corpor/ Tue, 24 May 2022 13:10:41 +0000 https://rogalevich.org/liver-disease-diagnostics-market-2022-by-key-players-and-suppliers-abbott-horiba-medical-randox-laboratories-roche-fujifilm-corporation-thermo-fisher-scientific-labcorp-boston-scientific-corpor/ New Jersey (USA) – The Liver Disease Diagnostics market research is an intelligence report with meticulous efforts undertaken to study the correct and valuable information. The data that has been reviewed takes into account both existing top players and upcoming competitors. The business strategies of key players and new industries entering the market are studied […]]]>

New Jersey (USA) – The Liver Disease Diagnostics market research is an intelligence report with meticulous efforts undertaken to study the correct and valuable information. The data that has been reviewed takes into account both existing top players and upcoming competitors. The business strategies of key players and new industries entering the market are studied in detail. A well-explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Get the Sample PDF Copy (Including Full TOC, Graphs and Tables) of this Report@ https://www.maccuracyreports.com/report-sample/451499

Some of the major companies influencing this market include:

Abbott, Horiba Medical, Randox Laboratories, Roche, Fujifilm Corporation, Thermo Fisher Scientific, LabCorp, Boston Scientific Corporation, Siemens Healthcare GmbH

Various factors are responsible for the growth trajectory of the market, which are studied extensively in the report. In addition, the report enumerates the restraints that pose a threat to the diagnosis of liver diseases globally .This report is a consolidation of primary and secondary research, which provides market size, share, dynamics and forecasts for various segments and sub-segments considering macro and micro environmental factors. It also assesses the bargaining power of suppliers and buyers, the threat of new entrants and product substitutes, and the degree of competition prevailing in the market.

Types of Liver Disease Diagnostics Market:

Imaging tests, blood tests, biopsy, others.

Liver Disease Diagnostics Market Applications:

Hospitals, Laboratories, Others

The report studies the key segments of the global Liver Disease Diagnostics industry, their growth over the past few years, the profiles and market size of the individual segments, and provides a detailed overview of the profiles of the various segments. The report also presents the key products and various other products of the global Liver Disease Diagnostics industry along with its market size and growth over the study period. The key drivers of demand for the products and services of the global Liver Disease Diagnostics industry are profiled in the report. The Liver Disease Diagnostics report details some major success factors and risk factors for investing in certain segments.

The report provides information about the following pointers:

Market penetration: Comprehensive data on the product portfolios of major players in the Liver Disease Diagnostics Market.

Product Development/Innovation: Detailed information on upcoming technologies, R&D activities and product launches in the market.

Competitive evaluation: An in-depth analysis of the market strategies of major companies in the market, along with their geographical and business segments.

Market development: Information on developing markets in full. This study examines the market in several geographies for different segments.

Market Diversification: Detailed data on new products, untapped geographies, recent advancements, and investment opportunities in the Liver Disease Diagnostics market.

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The cost analysis of the Global Liver Disease Diagnostics Market has been performed while considering the manufacturing expense, labor cost, and raw materials along with their market concentration rate, vendors and the price trend. Other factors such as supply chain, downstream buyers, and sourcing strategy have been assessed to provide a comprehensive and in-depth view of the market. Buyers of the report will also be exposed to market positioning study with factors such as target customer, brand strategy, and pricing strategy taken into consideration.

Key questions covered in this report?

  1. A comprehensive overview of different geographic breakdowns and common product categories in the Liver Disease Diagnostics market.
  2. When you have information about cost of production, cost of products and cost of production for the coming years, you can repair the developing databases for your industry.
  3. In-depth burglary analysis for new companies seeking to enter the Liver Disease Diagnostics Market.
  4. How do top and mid-tier companies make money in the market?
  5. Conduct an in-depth study on the overall Liver Disease Diagnostics market status to aid in the selection of product launches and reviews.

Contents

Global Liver Disease Diagnostics Market Research Report 2022-2029

Chapter 1 Liver Disease Diagnostics Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 – Global Liver Disease Diagnostics Market Forecast

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If you have any special requirements, please let us know and we will offer you the report you want.

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Only Fools And Horses star Patrick Murray announces his lung cancer is ‘cured’ | Ents & Arts News https://rogalevich.org/only-fools-and-horses-star-patrick-murray-announces-his-lung-cancer-is-cured-ents-arts-news/ Sun, 22 May 2022 17:43:26 +0000 https://rogalevich.org/only-fools-and-horses-star-patrick-murray-announces-his-lung-cancer-is-cured-ents-arts-news/ British sitcom star Patrick Murray has said his lung cancer was ‘cured’ and a tumor found in his liver was ‘shrinking’ in response to treatment. Murray, 65, who played Mickey Pearce in Only Fools And Horses, revealed his diagnosis earlier this year. He said scans detected a cancerous lung tumor which he had undergone an […]]]>

British sitcom star Patrick Murray has said his lung cancer was ‘cured’ and a tumor found in his liver was ‘shrinking’ in response to treatment.

Murray, 65, who played Mickey Pearce in Only Fools And Horses, revealed his diagnosis earlier this year.

He said scans detected a cancerous lung tumor which he had undergone an operation to remove, alongside chemotherapy.

Follow-up scans found another tumor in his liver which he said was unrelated to his lung cancer, which was also treatable.

He said he was treated with Tace, or transcatheter arterial chemoembolization, which is a combination of chemotherapy and other drugs designed to restrict the blood supply to the tumor.

In a Twitter update, he wrote, “Thank you again for all your lovely messages. As you may know, I was diagnosed with lung cancer last July.

“After an operation in October to remove the tumour, I had chemo to help prevent the cancer from coming back. During this chemo, another tumor was discovered in my liver.

“Fortunately for me, this cancer was unrelated to lung cancer and treatable as well. I had a procedure called Tace to deal with it.

“Last Friday I saw my oncologist. She told me that the lung cancer was cured and my liver tumor was shrinking.

“It’s not over yet, but as you can imagine, I’m over the moon with this latest news.”

John Challis, who played Boycie in Only Fools And Horses, died of cancer aged 79 Last year.

Challis’ family said in a statement at the time that he died “peacefully in his sleep, after a long battle with cancer.”

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Newborn baby shows liver damage after first dose of Remdesivir: The Tribune India https://rogalevich.org/newborn-baby-shows-liver-damage-after-first-dose-of-remdesivir-the-tribune-india/ Sat, 21 May 2022 02:28:00 +0000 https://rogalevich.org/newborn-baby-shows-liver-damage-after-first-dose-of-remdesivir-the-tribune-india/ Tribune press service Naina Mishra Chandigarh, May 20 IGP researchers have reported a bizarre case of a 14-day-old Covid-19 positive child showing liver damage after being injected with Remdesivir, a drug widely used in Covid-19 patients during the second wave . The research paper expressed alarm against the use of Remdesivir in less […]]]>


Tribune press service

Naina Mishra

Chandigarh, May 20

IGP researchers have reported a bizarre case of a 14-day-old Covid-19 positive child showing liver damage after being injected with Remdesivir, a drug widely used in Covid-19 patients during the second wave . The research paper expressed alarm against the use of Remdesivir in less severe patients.

Doctors at the Center for Advanced Pediatrics, PGI, presented the case of a newborn in an article titled, “Remdesivir-induced liver injury in a Covid-positive newborn,” published in the Indian Journal of Paediatrics.

According to the newspaper, a newborn with Covid-19, who suffered from severe hypoxemia (low oxygen levels) requiring intubation, was admitted to the IGP. When remdesivir was given, the baby experienced worsening transaminitis (liver inflammation) requiring drug discontinuation, after which liver enzymes normalized over the next two weeks.

The 14-day-old breastfed baby developed poor feeding, lethargy and rapid breathing on day 13 of his life. The baby was in respiratory distress requiring continuous positive airway pressure (CPAP). The chest X-ray suggested viral pneumonia and the baby tested positive for Covid. The baby had worsening distress and was intubated on day 5 of the hospital stay.

Given the possibility of severe Covid pneumonia, the baby was injected with Remdesivir. After starting Remdesivir, the baby had severe inflammation of the liver after his first dose.

The researchers say drug-induced liver damage versus Covid infection-induced hepatitis was considered and Remdesivir was stopped after the first dose.

The researchers said the child’s liver enzymes gradually normalized on day 15 of the hospital stay and the baby was discharged on day 18 while breastfeeding.

Since derangement and improvement in liver function tests had a temporal association with starting and stopping Remdesivir treatment, respectively, drug-induced liver injury was considered more likely, the doctors said. .

“Remdesivir has shown a decrease in length of hospitalization and a modest survival benefit in moderate and severe Covid infections in adult patients. Remdesivir can increase transaminases and has been avoided in patients with pre-existing hepatic impairment. Remdesivir should be used with caution and limited only to cases of severe Covid infection,” the article read.

The research paper reads

“Remdesivir has shown a decrease in length of hospitalization and a modest survival benefit in moderate and severe Covid infections in adult patients. Remdesivir can increase transaminases and has been avoided in patients with pre-existing hepatic impairment. Remdesivir should be used with caution and limited only to cases of severe Covid infection,” the article read.

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Mysterious childhood hepatitis outbreak reaches New Jersey https://rogalevich.org/mysterious-childhood-hepatitis-outbreak-reaches-new-jersey/ Wed, 18 May 2022 20:59:00 +0000 https://rogalevich.org/mysterious-childhood-hepatitis-outbreak-reaches-new-jersey/ The epidemic of mysterious cases of hepatitis in children has spread to New Jersey. The Centers for Disease Control and Prevention is investigating four pediatric cases in the Garden State that may be linked to acute liver disease, the state Department of Health said in a statement Wednesday. The children studied are between the ages […]]]>

The epidemic of mysterious cases of hepatitis in children has spread to New Jersey.

The Centers for Disease Control and Prevention is investigating four pediatric cases in the Garden State that may be linked to acute liver disease, the state Department of Health said in a statement Wednesday.

The children studied are between the ages of 1 and 7 years old. All survived and did not need a liver transplant.

“All were previously hospitalized between October 2021 and February 2022, and all have recovered,” the statement said. “None of the children had a liver transplant. All of the children tested negative for COVID. There were no deaths. »

The mysterious illness has affected more than 110 children in nearly 30 US states. About 300 probable cases have been identified worldwide.

The cases have baffled medical experts.

The cause of the life-threatening liver inflammation is still unclear, but experts believe it could be linked to the adenovirus, which can cause the common cold.

Although serious, the disease remains rare.

“It’s a new phenomenon,” Vinod Rustgi, a distinguished professor of medicine and director of hepatology at Rutgers Robert Wood Johnson School of Medicine, told NJ Advance Media last week. “There have been clusters, but that’s by no means a very common occurrence, even with the number of cases that have been reported.”

Concerned parents should look for signs of fever, nausea, vomiting, diarrhea and abdominal pain. Many children had jaundice – yellowing of the skin or eyes – and were found to have abnormally high levels of liver enzymes.

The state health department issued an alert in April advising healthcare providers to watch for suspected cases of hepatitis of unknown origin. The collected data was then sent to the CDC, which analyzed it to determine which cases met the criteria.

According to the CDC, five children have died from baffling liver disease in the United States, and 14% of patients required transplants. Its website shows 180 “people under investigation” for acute hepatitis in 36 states, although the agency notes that “PUI does not mean this person is a confirmed case.”

“States and CDC are reviewing extensively (including cases of hepatitis of unknown origin in children under 10, since October 2021), so this number may increase or decrease as CDC and States review medical records and learn more.”

Our journalism needs your support. Please subscribe today to NJ.com.

Spencer Kent can be reached at skent@njadvancemedia.com.

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CANbridge-UMass Chan Medical School Gene Therapy Research Presented at American Society of Gene and Cell Therapy (ASGCT) Annual Meeting https://rogalevich.org/canbridge-umass-chan-medical-school-gene-therapy-research-presented-at-american-society-of-gene-and-cell-therapy-asgct-annual-meeting/ Tue, 17 May 2022 00:10:51 +0000 https://rogalevich.org/canbridge-umass-chan-medical-school-gene-therapy-research-presented-at-american-society-of-gene-and-cell-therapy-asgct-annual-meeting/ First study from CANbridge UMass collaboration shows new gene therapy holds promise for clinical applications in spinal muscular atrophy BEIJING AND CAMBRIDGE, Massachusetts, May 17, 2022–(BUSINESS WIRE)–CANbridge Pharmaceuticals Inc. (HKEX:1228), a leading global biopharmaceutical company based in China and committed to the research, development and commercialization of transformative therapies for rare diseases and oncology rare, […]]]>

First study from CANbridge UMass collaboration shows new gene therapy holds promise for clinical applications in spinal muscular atrophy

BEIJING AND CAMBRIDGE, Massachusetts, May 17, 2022–(BUSINESS WIRE)–CANbridge Pharmaceuticals Inc. (HKEX:1228), a leading global biopharmaceutical company based in China and committed to the research, development and commercialization of transformative therapies for rare diseases and oncology rare, announced the presentation of initial data from its gene therapy research agreement with the Horae Gene Therapy Center, at UMass Chan Medical School, at ASGCT 25and Annual meeting, in Washington DC, today.

In work led by Jun Xie Ph.D., in the laboratory of Guangping Gao, Ph.D., researchers concluded that a novel second-generation scAAV9 gene therapy, expressing co-hSMN1 from an hSMN1 promoter endogenous, demonstrated superior potency, efficacy and safety in spinal muscular atrophy (SMA) mice, compared to the reference vector, scAAV9-CMVen/CB-hSMN1, which is similar to the vector used in gene therapy approved by the United States Food and Drug Administration for the treatment of SMA.

The new second-generation gene therapy showed superior efficacy to the reference vector in SMA mice on several parameters, including extended lifespan, restored muscle function, and better innervation of the neuromuscular junction, without the liver toxicity shown in reference treated animals. Specifically, second-generation gene therapy significantly extended the lifespan of SMA mice in a dose-dependent manner, with all doses showing improved survival, compared to the high dose of reference gene therapy vector and SMA mice. untreated. Second-generation gene therapy also restored muscle function in SMA mice significantly better than the reference vector. This was observed in both the righting test, in which SMA mice treated with second-generation gene therapy were able to right more quickly than vector-treated control mice, and in the grid test, in which they demonstrated better muscle function. In addition, the second-generation vector restored the innervation of neuromuscular junctions in SMA mice close to that of wild-type mice, and significantly better than in SMA mice treated with the reference vector.

Finally, SMA mice treated with the second-generation gene therapy showed higher SMN1 expression in the central nervous system and lower peripheral tissues than mice treated with the reference vector, in a similar pattern to carrier mice. healthy. Additionally, the reference vector produced liver damage in four out of seven SMA mice, eight days after injection, compared to no liver toxicity in mice treated with the second-generation gene therapy vector, or in healthy carrier mice, suggesting that second-generation gene therapy has the potential to reduce liver toxicity and overcome current therapeutic limitations.

This is the first data presented as part of the gene therapy research collaboration between CANbridge and the Gao Laboratory at the Horae Gene Therapy Center.

“What differentiates our novel second-generation gene therapy vector from the reference vector is the genetic engineering of a codon-optimized SMN1 transgene under the control of the endogenous SMN1 promoter, which allows for highly efficient and regulated gene expression at through tissues, with the potential to improve both efficacy and safety, while being at a lower dose than currently used in patients,” said Yunxiang Zhu, Ph.D., Vice President, Global Research Lead, CANbridge Pharmaceuticals and Study Author “These data encourage us to support the continued development of this second-generation vector as a potential first-in-class gene therapy for SMA.”

“We seek to develop a next-generation gene therapy for SMA that takes advantage of advances in gene therapy since the development of the first gene therapy more than a decade ago,” said Guangping Gao, Ph.D. , co-director. , Li Weibo Institute for Rare Diseases Research, Director of the Horae Gene Therapy Center and Viral Vector Core, Professor of Microbiology and Physiological Systems and Penelope Booth Rockwell Professor of Biomedical Research at UMass Chan Medical School, and lead author of the study. Dr. Gao is also a past president of ASCGT.

Presentation details:

Title: Endogenous Human SMN1 Promoter-Induced Gene Replacement Improves Efficacy and Safety of AAV9-Mediated Gene Therapy for Spinal Muscular Atrophy in Mice

Attach #: M-144

Category: Neurological diseases: AAV vectors – preclinical and proof of concept studies

Category: Neurological diseases I

Session date and time: Monday, May 16, 5:30-6:30 p.m. EDT

Authors: Qing Xie, Hong Ma, Xiupeng Chen, Yunxiang Zhu, Yijie Ma, Leila Jalinous, Qin Su, Phillip Tai, Guangping Gao, Jun Xie

Abstracts are available on the ASGCT website: https://annualmeeting.asgct.org/abstracts

About UMass Chan Medical School Horae Gene Therapy Center

The faculty of the Horae Gene Therapy Center is dedicated to developing therapeutic approaches for rare inherited diseases for which there is no cure. We use state-of-the-art technologies to either genetically modulate mutated genes that produce disease-causing proteins, or introduce a healthy copy of a gene if the mutation results in a non-functional protein.

The faculty at the Horae Gene Therapy Center is interdisciplinary and includes members from the departments of Pediatrics, Microbiology and Physiological Systems, Biochemistry and Molecular Pharmacology, Neurology, Medicine, and Ophthalmology. Physicians and doctors work together to meet the medical needs of rare diseases, such as alpha 1-antitrypsin deficiency, Canavan disease, Tay-Sachs and Sandhoff diseases, retinitis pigmentosa, cystic fibrosis, Lou Gehrig’s disease, TNNT1 nemaline myopathy, Rett’s syndrome, N-Gly 1 deficiency, Pitt-Hopkins syndrome, Marple syrup urinary disease, sialidosis, GM3 synthase deficiency, Huntington’s disease, ALS and others . More common diseases such as cardiac arrhythmia and hypercholesterolemia are also studied. The hope is to treat a wide range of diseases by various gene therapy approaches. Additionally, the University of Massachusetts Chan Medical School conducts on-site clinical trials and some of these trials are conducted by investigators from the gene therapy center.

About CANbridge Pharmaceuticals Inc.

CANbridge Pharmaceuticals Inc. (HKEX: 1228) is a China-based global biopharmaceutical company dedicated to the research, development and commercialization of transformative therapies for rare diseases and rare oncology. CANbridge has a differentiated drug portfolio, with three approved drugs and a pipeline of 11 assets, targeting prevalent rare diseases and rare oncology indications that have unmet need and significant market potential. These include Hunter syndrome and other lysosomal storage disorders, complement-mediated disorders, hemophilia A, metabolic disorders, rare cholestatic liver diseases and neuromuscular diseases, and glioblastoma multiforme. CANbridge is also developing next-generation gene therapy development capability through collaboration with world-renowned researchers and biotech companies and in-house capability. CANbridge’s global partners include: Apogenix, GC Pharma, Mirum, Wuxi Biologics, Privus, UMass Chan Medical School and LogicBio.

To learn more about CANbridge Pharmaceuticals Inc., visit: www.canbridgepharma.com.

Forward-looking statements

Forward-looking statements made in this article relate only to events or information as of the date the statements are made in this article. Except as required by law, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, following the data on which the statements are made or to reflect the occurrence of unforeseen events. events. You should read this article in its entirety and be aware that our actual future results or performance may differ materially from what we expect. In this article, statements or references to our intentions or those of any of our directors or our company are made as of the date of this article. Each of these intentions may change in light of future development.

See the source version on businesswire.com: https://www.businesswire.com/news/home/20220516005913/en/

contacts

Relations with American investors:
Chris Brinzey
ICR Westwicke
Chris.brinzey@westwicke.com

China Investor Relations
CANbridge Pharmaceuticals Inc.
ir@canbridgepharma.com

Media:
Deanne Eagle
Planet Communications
deanne@planetcommunications.nyc
917.837.5866

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Paracetamol: side effects include ‘fatal’ liver damage – ‘talk to doctor’ https://rogalevich.org/paracetamol-side-effects-include-fatal-liver-damage-talk-to-doctor/ Sun, 15 May 2022 08:58:00 +0000 https://rogalevich.org/paracetamol-side-effects-include-fatal-liver-damage-talk-to-doctor/ “An overdose of paracetamol can cause serious side effects,” says the NHS. “Don’t be tempted to increase the dose or take a double dose if your pain is very bad.” This warning is based on the popular painkiller’s ability to cause liver or kidney damage. Whether you’re taking paracetamol to relieve a headache or to […]]]>

“An overdose of paracetamol can cause serious side effects,” says the NHS. “Don’t be tempted to increase the dose or take a double dose if your pain is very bad.” This warning is based on the popular painkiller’s ability to cause liver or kidney damage.

Whether you’re taking paracetamol to relieve a headache or to bring down your temperature, the common pain reliever should be taken in sufficient amounts.

The usual recommended dose for adults is one or two 500 mg tablets up to four times a day.

Otherwise, you could risk liver or kidney damage, the NHS warns.

Worse, the health service explains that these side effects could be “fatal” in some cases.

READ MORE: Bowel cancer: Deborah James on early symptoms – ‘I knew there was something wrong’

This NHS warning is also backed up by studies, as researchers have found this harmful effect of paracetamol.

Dr Leonard Nelson, from the University of Edinburgh, said: “Paracetamol is the world’s favorite pain remedy.

“It’s cheap and considered safe and effective at therapeutic doses.

“However, drug-induced liver injury remains an important clinical problem and a challenge for the development of safer drugs.

DO NOT MISS

“Our findings reinforce the need for vigilance in the use of paracetamol and could help uncover how harm from its unwanted use could be prevented.”

The research, published in Scientific Reports, examined the impact of paracetamol on liver cells in human and mouse tissues.

The findings suggest that pain relief may damage the liver by damaging vital structural connections between adjacent cells in the organ in some cases.

When these cell wall connections are disrupted, the structure of liver tissue is damaged.

This leaves your cells unable to function properly and they can die, explains the British Liver Trust.

This type of cell damage is similar to that seen in serious conditions such as hepatitis, cirrhosis and cancer.

Scientists are now looking to determine how varying doses and timescales affect this toxicity.

Co-author Dr Pierre Bagnaninchi said: “Although liver damage caused by paracetamol toxicity has been extensively studied for the past 40 years, recent developments in biosensor technology make it possible to have a more complete picture of the biological mechanisms involved.”

The NHS adds that paracetamol “very rarely” triggers side effects if you stick to the correct dosage.

The study findings also echo this recommendation, urging not to exceed the dose within 24 hours.

Remember to stick to one or two 500mg tablets up to four times in 24 hours or as advised by your doctor.

“If you’re concerned about a side effect or notice anything unusual, talk to your pharmacist or doctor,” advises the health department.

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Liver disease during the COVID-19 pandemic https://rogalevich.org/liver-disease-during-the-covid-19-pandemic/ Fri, 13 May 2022 17:04:11 +0000 https://rogalevich.org/liver-disease-during-the-covid-19-pandemic/ Americans were plagued by sedimentary lifestyles long before the COVID-19 pandemic. Teenagers opting for video games over sports, office workers spending long hours without a break, and other down time watching television negatively impact the health of many people. Then, when the pandemic added with gym closings and social opportunities canceled, the health of many […]]]>

Americans were plagued by sedimentary lifestyles long before the COVID-19 pandemic.

Teenagers opting for video games over sports, office workers spending long hours without a break, and other down time watching television negatively impact the health of many people.

Then, when the pandemic added with gym closings and social opportunities canceled, the health of many suffered greatly.

One such disease that people with a sedimentary lifestyle are prone to is non-alcoholic fatty liver disease (NAFLD).

In an interview with HCPLive®Sanjiv Chopra, MD, Professor of Medicine, Harvard Medical School, that the pandemic has had a profound impact on an already growing liver disease problem.

Chopra also said alcoholic hepatitis rates have increased during the pandemic.

“People were drinking more, maybe because they were stressed and had access to alcohol,” he said. “They weren’t exercising, weren’t eating comfort food, and were stressed out.”

However, for many of these liver diseases, simple lifestyle fixes could make a big difference.

Chopra said even losing a little weight has a profound impact on NAFLD risk. Other tips include drinking coffee regularly, supplementing with vitamin D, and taking regular breaks from work when possible to avoid sitting for long periods at a time.

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Sonu Sood reveals how he gets his charity work sponsored https://rogalevich.org/sonu-sood-reveals-how-he-gets-his-charity-work-sponsored/ Wed, 11 May 2022 06:49:58 +0000 https://rogalevich.org/sonu-sood-reveals-how-he-gets-his-charity-work-sponsored/ In a new interview, Sonu Sood shared how he manages finances by helping those in need. The actor has become a household name during the Covid pandemic for his charity work. Sonu Sood said in a new interview that when asked to promote a particular hospital, he demanded 50 liver transplants – worth ₹12 crore […]]]>

In a new interview, Sonu Sood shared how he manages finances by helping those in need. The actor has become a household name during the Covid pandemic for his charity work.

Sonu Sood said in a new interview that when asked to promote a particular hospital, he demanded 50 liver transplants – worth 12 crore – as fresh. Sonu has been actively helping people with medical, educational and financial needs for the past two years. (Read also: Sonu Sood reveals that his scenes in Acharya have been reworked)


When the pandemic hit and the subsequent lockdowns were installed, Sonu began by helping people, mostly immigrants, get to their hometowns and ease their financial constraints. Soon, people were throwing requests for their medical and educational needs and the actor mostly answered them with the required help.

Sonu told The Man magazine in an interview, “For my last mentions, all the money I made, I asked them to give it to charity. Sometimes they give it directly to a school or to a hospital, sometimes they pass it through our charity – we are open to anything I’ll give you a small example: a gentleman called Wilson from Aster Hospitals contacted me on a recent trip to Dubai and said that the group would like to partner with me to help people with their medical needs.”


He added: “So I said I would promote hospitals, but give me 50 liver transplants. That’s almost 12 crore in value. As we speak, there are two transplants underway for people who could never afford these surgeries. It’s the magic of connecting the dots. People come to you and tell you how can we help you and we find a way.”


Sonu was most recently seen in Chiranjeevi and Ram Charan-star Acharya. He played the antagonist in the film which hit theaters on April 29. He is also the host of the latest edition of the MTV reality show Roadies.

Next, Sonu will be seen alongside Akshay Kumar and Manushi Chillar in the upcoming historical drama, Prithviraj. Directed by Dr. Chandraprakash Dwivedi, the film is set to hit theaters on June 3.



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GlucoTrust Review – Does It Really Work?? Must read before buying!! {Latest Report 2022} Employment – 10th Security Forces Squadron – USAF https://rogalevich.org/glucotrust-review-does-it-really-work-must-read-before-buying-latest-report-2022-employment-10th-security-forces-squadron-usaf/ Sat, 07 May 2022 19:46:38 +0000 https://rogalevich.org/glucotrust-review-does-it-really-work-must-read-before-buying-latest-report-2022-employment-10th-security-forces-squadron-usaf/ GlucoTrust is made with a unique formula that helps control blood pressure in people with diabetes. Apart from this advantage, it also has several other advantages. It helps prevent type I and type II diabetes. It promotes the production of insulin and prevents the breakdown of glucose. What is GlucoTrust? GlucoTrust’s goal is to help […]]]>

GlucoTrust is made with a unique formula that helps control blood pressure in people with diabetes. Apart from this advantage, it also has several other advantages. It helps prevent type I and type II diabetes. It promotes the production of insulin and prevents the breakdown of glucose.

What is GlucoTrust?

GlucoTrust’s goal is to help you sleep better to control your blood sugar and boost your metabolism. If you have diabetes and its complications (such as high blood pressure, liver disease and embolisms), taking Glucotrust can also help you manage them. Deep sleep can be achieved using GlucoTrust’s formula. The formula uses natural nutrients to keep you healthy and prevent your blood sugar from rising.

(OFFICIAL OFFER) ++Click here to order GlucoTrust from its official online store.++

According to GlucoTrust creator James Walker, the supplement also contains several sleep-inducing ingredients. In addition, leptin, the hormone that regulates your appetite, is stimulated, which helps keep cortisol in check. Your body’s ability to regulate hormones is improved with more sleep. GlucoTrust is produced in the United States, in an FDA-approved facility, according to official sources. The company claims that GlucoTrust capsules do not contain any chemicals, fillers, or stimulants that may reduce their effectiveness.

GlucoTrust Ingredient Rating:

Glucotrust can help effectively manage diabetes. You can expect to find a powerful blend of vitamins, herbs and other natural ingredients in Glucotrust tablets.

Let’s take a closer look at these ingredients and their benefits:

Sylvester Gymnema

The leaves of this plant have been used in ancient Indian medicine for millennia. While suppressing your sugar cravings, this nutrient is believed to help restore healthy blood sugar levels.

Biotin

Enzymes and nutrients are transported throughout your body using biotin. Diabetic patients may find this helpful in controlling their blood sugar. Biotin, also known as the B vitamin, can help your body better convert food into energy and better metabolize carbohydrates, fats, and proteins. A daily dose of biotin is recommended.

(OFFICIAL OFFER) ++Click here to order GlucoTrust from its official online store.++

Chromium

The essential trace element chromium can improve protein function, carbohydrates, lipid metabolism and blood sugar levels. You will be able to burn belly fat faster with the help of this ingredient, which boosts your metabolism.

READ ALSO: How does Glucofort work?

Zinc

Enzymes that aid digestion, nerve function and metabolism depend on zinc for their proper function. Besides its immune function, zinc also plays a structural role in proteins by stabilizing them.

Manganese

Manganese helps in the production of insulin, which converts glucose in the blood into usable energy. It also helps maintain a healthy brain and nervous system.

juniper berries

As an antidiabetic and antibacterial agent, juniper berry extract has been widely used in medicinal supplements. The treatment of gastrointestinal and autoimmune disorders is effective using juniper berries.

licorice root

Chronic diseases such as diabetes can be prevented and reversed with the help of licorice root. Its antioxidants improve heart function and increase insulin sensitivity.

Cinnamon

Adding cinnamon to your diet is a great way to enhance flavor. For thousands of years it has been revered for its medicinal qualities. Cinnamon has been shown to significantly reduce insulin resistance, allowing this vital hormone to perform its vital role in our bodies. Cinnamon can lower blood sugar levels by improving the ability of insulin to perform its functions.

(OFFICIAL OFFER) ++Click here to order GlucoTrust from its official online store.++

How to use GlucoTrust:

Supplementing with GlucoTrust is simple and hassle-free. The recommended dosage is one capsule with a glass of water or beverage of your choice each night before sleeping. According to the main website, the GlucoTrust blood sugar supplement was developed for adult customers only. People over the age of 20 to 30 who are at high risk for developing blood sugar problems and type 2 diabetes may find this all-natural treatment reliable. Also, pregnant women should avoid using it. To be on the safe side, it is best to consult a doctor before trying any new supplement.

Purchase of Glucotrust

Getglucotrust.com is the official website and where GlucoTrust can be purchased. Consumers who find it in a retail store or online should avoid it as it could be a scam. Take advantage of the company’s great pricing, 60-day money-back guarantee, and official website pricing.

Below, you will find additional information on Glucotrust’s prices and packages:

  • 1 bottle of GlucoTrust: $69.00 each + $9.00 shipping
  • 3 bottles of GlucoTrust: $59.00 each, free shipping included
  • 6 bottles of GlucoTrust: $49.00 each, free shipping included

You should buy Glucotrust in bulk because it is a natural product that takes time to work.

Besides the cost savings, buying in bulk ensures that you will have a constant supply of the product for a longer period of time, thus avoiding the need for a monthly order. It’s always best to start with just one bottle if you’ve never used Glucotrust before or aren’t sure how many bottles to buy. Then try it for a month to see if it works for you.

(OFFICIAL OFFER)++ Click here to order GlucoTrust from its official online store.++

Bonus items:

The following items are also included in your bonus order. Your Glucotrust order will come to you with a link to a personalized page on the leading site where you can download these bonuses to your smartphone, tablet or computer system.

Bonus #1: Fat Burning Smoothie Recipes

You’ll learn how to make delicious, nutrient-dense smoothies with this bonus article. It contains 100 smoothie recipes, which can be made with ingredients you can find at your local supermarket. A wide variety of superfoods are used in all the recipes in this eBook. This cookbook is a must-have because its recipes are delicious and healthy and can help you lose weight.

Bonus #2: The Ultimate Guide to Superfoods

Unlike processed or canned foods, superfoods provide complete support for your body. In this freebie, you’ll learn about the health benefits of some of your favorite foods. You will discover various foods specially designed to reduce fatty liver disease.

Bonus #3: The Liver Cleanse Breakthrough in 3 Days

Your liver is like a sponge, absorbing and processing the food you eat. As a result, you may have accumulated toxic substances in this organ that have affected your energy, mood, immune system, and weight loss efforts. It teaches you the tips and techniques to naturally cleanse your liver in just three days.

GlucoTrust Refund Policy:

No one wants to waste their income considering the growing number of supplements that don’t work. Therefore, the company has implemented a refund policy to assure customers who are still undecided. To return a product, customers have 60 days from the date of purchase to do so. Contacting company customer service is the best way to get a refund by emailing one of the email addresses below:

++(OFFICIAL OFFICE) Click here to order GlucoTrust from its official online store.++

Concluding remarks:

Marketed as a blood sugar and sleep support formula, GlucoTrust works effectively. GlucoTrust can help you achieve optimal glucose levels in just days without the need for insulin or any other potentially harmful prescription medication. Sleeping better at night triggers a chain of events that drive metabolism and regulate blood sugar levels without further change. Because this formula allows customers to improve their blood sugar levels while they sleep, it stands out from the crowd. Additionally, long-term use of this supplement may lead to improved metabolic function. The active ingredients of GlucoTrust have proven to be safe, thanks to the natural formulation. Over tens of thousands of adults claim to have been able to manage their blood sugar levels since the introduction of the GlucoTrust formula.

So what’s holding you back? ++Get GlucoTrust today!++

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you choose to purchase the recommended product at no additional cost to you. This serves to support our research and writing team and please know that we only recommend high quality products.

Warning:

Please understand that any advice or guidance revealed here does not even remotely replace sound medical advice from a licensed health care provider. Be sure to consult a professional doctor before making any purchasing decisions if you are using any medications or have any concerns from the review details shared above. Individual results may vary because statements made regarding these products have not been evaluated by the Food and Drug Administration. The effectiveness of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

The news and editorial team at Sound Publishing, Inc. played no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

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