Causes of death in patients with non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and chronic viral hepatitis B and C


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Anne Hépatol. November 17, 2021: 10556. doi: 10.1016 / j.aohep.2021.100556. Online ahead of print.


INTRODUCTION AND OBJECTIVES: The cause of death in patients with chronic liver disease (CHD) may differ depending on the underlying etiology of the liver disease. Our goal was to assess different causes of death in patients with the most common types of CPM using a US national database.

MATERIALS AND METHODS: 2008 and 2018 death data from the National Vital Statistics System (NVSS) of the National Center for Health Statistics (NCHS) were used. The rank of cause of death for each etiology of CPM was assessed. The causes of death were classified according to ICD-10 codes. Liver-related deaths included liver cancer, cirrhosis, and CPD.

RESULTS: Of a total of 2,826,531 deaths in 2018, there were 85,807 (3.04%) with underlying CGD (mean age at death 63.0 years, 63.8% males, 70 , 8% white). Liver-related mortality was the leading cause of death for all types of CPM [45.8% in non-alcoholic fatty liver disease (NAFLD), 53.0% in chronic hepatitis C (CHC), 57.8% in chronic hepatitis B (CHB), 81.8% in alcoholic liver disease (ALD)]. Next come cardiac deaths (NAFLD 10.3%, CHC 9.1%, CHB 4.6%, ALD 4.2%) and extrahepatic cancer (NAFLD 7.0%, CHC 11.9%, CHB 14.9%, ALD 2.1%). Although liver cancer is the leading cause of cancer death, lung, colorectal and pancreatic cancers were also common causes of cancer deaths.

CONCLUSIONS: Among the deceased patients with CPM, underlying liver disease was the leading cause of death. Among solid cancers, liver cancer was the leading cause of cancer-related death.

PMID: 34800721 ​​| DOI: 10.1016 / j.aohep.2021.100556


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