Disparities in advanced liver cancer risk and mortality by race and ethnicity
This article was originally published here
J Natl Cancer Inst. May 12, 2022: djac097. doi: 10.1093/jnci/djac097. Online ahead of print.
BACKGROUND: In the United States, liver cancer is the 5th and 7th most common cause of cancer-related death in men and women, respectively. Compared to other racial/ethnic groups in the United States, Asian and Pacific Islander populations experience the highest incidence rates of liver cancer, but little is known about disparities in disease risk between advanced stage or risk of liver cancer mortality in these heterogeneous populations. All statistical tests were two-sided.
METHODS: In a population-based cohort of 60,146 patients aged 20-79 years diagnosed with liver cancer between 2004 and 2018, identified through the Surveillance, Epidemiology and Endpoints Program, we examined associations between race/ethnicity, including specific Asian and Pacific Islander people. subgroups, and the risk of advanced liver cancer and liver cancer-specific mortality.
RESULTS: Compared with non-Hispanic white patients, non-Hispanic black, Filipino, and Laotian patients had a 30% to 85% elevated chance of being diagnosed with stage IV liver cancer, while Hispanic, Vietnamese, and Chinese patients had 7-33% lower odds of being diagnosed with stage IV liver cancer (all p values
CONCLUSIONS: Substantial variations in the risk of advanced liver cancer and the risk of liver cancer mortality were observed by race and ethnicity, including considerable heterogeneity between individuals broadly defined as Asians and Pacific Islanders. Further efforts to understand the contributors to these disparities are needed to inform potential targeted screening and treatment interventions.