Drinking coffee may reduce the risk of fibrosis in liver disease

The researchers said the result meant it could be immediately used in real-life situations, as increased coffee consumption may benefit patients at risk of advanced liver disease.

The study indicates that patients chronically infected with hepatitis B virus (HBV) are at high risk of liver fibrosis, cirrhosis and liver cancer, despite recent therapeutic advances.

They added: “It is therefore crucial to find non-pharmaceutical options for the prevention of liver fibrosis in this population.

“Based on cross-sectional data from the ANRS CO22 Hepather cohort, we sought to identify the socio-demographic and modifiable risk factors for significant fibrosis in chronic HBV patients.​.”

Observational study

The ANRS CO22 HEPATHER cohort is a French therapeutic option for humans and a multicenter, national, prospective, observational study of patients infected with the hepatitis B or C virus.

The researchers said logistic regression models were used to test associations between explanatory variables and significant fibrosis, assessed by three noninvasive markers: platelet aspartate aminotransferase ratio index, FIB-4 and gamma ratio. platelet glutamyltransferase (GPR). Analyzes were stratified by hepatitis B treatment status.

The study population included 2065 untreated patients and 1727 patients treated for chronic hepatitis B.

The researchers concluded:High coffee consumption was consistently associated with a lower risk of elevated fibrosis biomarkers in all three treated participant models, suggesting a dose-response relationship.

Other modifiable risk factors included tobacco and alcohol consumption.

British Liver Trust

The British Liver Trust reports that regular consumption of moderate amounts of coffee can prevent liver cancer, with the World Health Organization confirming this after reviewing over 1,000 studies in humans. They said coffee also reduced the risk of other liver conditions, including fibrosis and cirrhosis.

They also wrote: “Drinking coffee may slow the progression of liver disease in some patients and beneficial effects have been found regardless of coffee preparation – filtered, instant and espresso.

Source: PubMed

Published: doi.org/10.1016/j.clnu.2022.01.016

High coffee consumption is associated with a lower risk of elevation of liver fibrosis biomarkers in patients treated for chronic hepatitis B (ANRS CO22 Hepather cohort)

Authors: Tangui Barré et al.

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