Madrigal fatty liver drug clears safety hurdle in late-stage study

Madrigal Pharmaceuticals said on Monday that its experimental pill significantly reduced liver fat by just under half without any serious safety concerns – meeting the goals of a “real-life” Phase 3 clinical trial involving patients with fatty liver disease known as NASH.

With just under 1,000 patients treated for one year, the main objective of the study was to demonstrate that Madrigal’s NASH treatment, called resmetirom, could be administered chronically without causing potentially harmful side effects.

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