Snoring and liver disease; Remicade’s COVID woes; Delays in the treatment of liver cancer

What is the connection between snoring and fatty liver disease? (Journal of Clinical Endocrinology and Metabolism)

An appeals court sided with AbbVie, saying the company’s 132 patents linked to its inflammatory bowel disease (IBD) drug, adalimumab (Humira) did not illegally block competition. (Reuters)

A study of 8 million pregnancies found that women with IBD were more likely to experience poor maternal and fetal outcomes. (University of Missouri-Columbia, International Journal of Colorectal Diseases)

Patients with Crohn’s disease who underwent ileocaecal resection were less likely to experience a recurrence if they started a tumor necrosis factor (TNF) inhibitor within 4 weeks of surgery rather than later. (Inflammatory bowel diseases)

Patients with IBD taking infliximab (Remicade) were more likely to experience COVID reinfections and breakthrough cases during the Omicron wave compared to those on vedolizumab (Entyvio), researchers reported in Intestine.

In a real-world study, Crohn’s disease patients taking anti-TNFs were more likely to achieve clinical response at 3 months than those on ustekinumab (Stelara), an IL-12/23 inhibitor. (Inflammatory bowel diseases)

Racial minority groups with ulcerative colitis may not respond as well to golimumab (Simponi), an analysis of the Yale Open Data Access Project was found. (Inflammatory bowel diseases)

For the first time, oral phage combination therapy can precisely target gut bacteria linked to IBD while sparing beneficial microbes, researchers reported in Cell.

In a randomized Phase II gluten challenge study in celiac disease, the investigational enzyme product latiglutenase (IMGX003) reduction in the severity of symptoms and damage to the intestinal mucosa. (Gastroenterology)

Surface protein assay based on extracellular vesicles has potential to bolster current surveillance methods for early detection of liver cancersay researchers in Hepatology.

Almost one in seven liver cancer patients experience treatment delays, with black people and people living in poverty being disproportionately affected. (Clinical gastroenterology and hepatology)

  • Zaina Hamza is a writer for MedPage Today, covering gastroenterology and infectious diseases. She is based in Chicago.

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