united states – Rogalevich http://rogalevich.org/ Sat, 26 Mar 2022 12:37:05 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://rogalevich.org/wp-content/uploads/2021/10/icon-120x120.png united states – Rogalevich http://rogalevich.org/ 32 32 Exelixis throws in the towel on early-stage liver cancer after final reading shows OS flop – Endpoints News https://rogalevich.org/exelixis-throws-in-the-towel-on-early-stage-liver-cancer-after-final-reading-shows-os-flop-endpoints-news/ Tue, 15 Mar 2022 10:36:01 +0000 https://rogalevich.org/exelixis-throws-in-the-towel-on-early-stage-liver-cancer-after-final-reading-shows-os-flop-endpoints-news/ The door to a label expansion for Exelixis’ Cabometyx is now completely closed. Exelixis held out a glimmer of hope – however slim – in the summer of last year, when it published mixed results from an interim reading of a phase III trial testing a combination of Cabometyx and Tecentriq from Roche versus Bayer’s […]]]>

The door to a label expansion for Exelixis’ Cabometyx is now completely closed.

Exelixis held out a glimmer of hope – however slim – in the summer of last year, when it published mixed results from an interim reading of a phase III trial testing a combination of Cabometyx and Tecentriq from Roche versus Bayer’s Nexavar in previously untreated liver cancer. But the final analysis turned out to be equally disappointing, as the combo was tied to “neither improvement nor detriment to the operating system”.

No numbers were provided – they are on file for a later medical meeting – but biotechnology has made it clear that this is now the end of the road.

Based on this OS result and the rapidly changing treatment landscape for previously untreated advanced HCC, Exelixis does not intend to submit an additional New Drug Application to the Food and Drug Administration ( FDA) of the United States.

Cabometyx, a tyrosine kinase inhibitor that hits a range of targets, has seen more than its share of ups and downs throughout the development journey. Two years before its first approval for second-line kidney cancer in 2016, the drug failed a key trial in prostate cancer.

Yet Exelixis continued to push for new indications, including through combined checkpoint approaches – leading to additional approvals in previously treated hepatocellular carcinoma (for liver cancer patients who have previously treated with Nexavar) and first-line renal cell carcinoma (in combination with Bristol Myers Squibb’s PD-1 Opdivo).

Vicki Goodman

The latest study, dubbed COSMIC-312, recruited 837 patients and focused on the first-line HCC setting.

Meanwhile, Cabometyx plus Tecentriq reduced the risk of disease progression or death by 37% compared to Nexavar. But it didn’t reach statistical significance on the OS, hinting at the end results – Exelixis admitted at the time that the probability of reaching the end point in the final scan was low.

“(W)e remain steadfast on our journey to further therapies for this and other difficult-to-treat cancers,” said Vicki Goodman, Chief Medical Officer.

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Liver Health Supplements Market Size, Latest Trends, Research Insights, Key Profile and Applications by 2030 – The Bollywood Ticket https://rogalevich.org/liver-health-supplements-market-size-latest-trends-research-insights-key-profile-and-applications-by-2030-the-bollywood-ticket/ Mon, 14 Mar 2022 06:06:41 +0000 https://rogalevich.org/liver-health-supplements-market-size-latest-trends-research-insights-key-profile-and-applications-by-2030-the-bollywood-ticket/ the global liver health supplements market the size is estimated at 827.24 million USD in 2020 and can reach $1,077.28 million, with a CAGR of 4.5% from 2021 to 2027. The liver is the largest internal organ that typically finds invertebrates, which play a crucial role in removing toxins from the body. Improving the health […]]]>

the global liver health supplements market the size is estimated at 827.24 million USD in 2020 and can reach $1,077.28 million, with a CAGR of 4.5% from 2021 to 2027. The liver is the largest internal organ that typically finds invertebrates, which play a crucial role in removing toxins from the body. Improving the health and well-being of the liver and keeping it functioning properly is a top priority for a healthy body. However, the prevalence of chronic liver diseases has recently increased due to various factors, such as decreasing food quality, increasing alcohol consumption, and many others. As a result, liver health supplements become a preferable option to enhance the smooth and healthy functioning of the liver in the human body.

Growing geriatric population, high incidence of obesity in children and adults, and increasing inclination towards fast food and alcohol consumption will increase the demand for liver health supplements, providing a enormous potential for growth in the global market.

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Factors such as increase in chronic liver diseases including alcoholic liver disease, chronic viral hepatitis, fatty liver disease, liver cancer and hemochromatosis are expected to drive the global growth of supplements market for liver health.

Growing consumer awareness of the need for good liver health coupled with growing government initiatives to promote good health is also fueling the growth of liver health supplements market in health and pharmaceutical sectors across the world.

However, stringent rules and regulations regarding liver health supplements and intense competition among major players may restrain the growth of the global liver health supplements market during the forecast period.

Impact of COVID-19 on Liver Health Supplements Market:

COVID-19 is a global contagious disease that has affected almost every industry, including healthcare and pharmaceuticals. The COVID-19 outbreak has increased the demand for liver health supplements globally, primarily in North America and Asia-Pacific. As the coronavirus crises engulf the world and lead to curfews and shutdowns, it has severely affected many companies operating across the globe, which has directly affected the production and demand for these supplements. This creates many lucrative opportunities for new players and small-scale players to mark their presence in the regional market and offer low prices and high quality products to end users. Therefore, with the outbreak of COVID-19, a significant increase in the demand for these supplements has been observed globally, which has positively impacted the liver health supplements market value in 2020. and the following years.

Report scope

The report outlines the liver health supplements market study based on product, dosage, and end-user.

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On the basis of product, the liver health supplements market has been segmented into –

  • Vitamins and minerals
  • herbal supplements
  • Others

On the basis of dosage, the liver health supplements market has been segmented into –

  • capsules
  • Tablets
  • Liquid
  • Others

Depending on the distribution channel, the market for liver health supplements has been segmented into –

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

Liver Health Supplements Market: Regional Outlook

Based on region, the global liver health supplements market has been segmented into five key geographical regions namely, North America, Asia-Pacific, Europe, South America, Middle East and Africa. In 2020, North America held the largest market share in the liver health supplements market, followed by Europe and Asia-Pacific, owing to the rise in beverage addiction alcohol abuse and a high prevalence of chronic liver disease in the region. On the contrary, Asia-Pacific is expected to show the highest CAGR during the forecast period, due to people’s increasing awareness of healthy products and increasing disposable income of individuals, as well as the presence growth of online retail platforms for drug supply in the region. .

Leading competitors in Liver Health Supplements Market include-

The market for liver health supplements is highly fragmented, with a large number of small players across the globe. Manufacturers of Vital Liver Health Supplements operating in the global market are-

  • Himalayan Herbal Health Care
  • Natures Craft Switzerland
  • Enzymedica
  • Thompson (Integria Healthcare)
  • Jarrow Formulas, Inc.
  • The bounty of nature
  • Irwin Natural
  • Swanson Health Products
  • NATURALife Health Products, Inc.
  • NOW Food

The Liver Health Supplements Market report provides an in-depth analysis of macroeconomic factors and market attractiveness of each segment. The report will include an in-depth qualitative and quantitative assessment of the industry/regional outlook with the presence of market players in the respective segment and region/country. The information concluded in the report includes the entries.

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Liver Health Supplements Market Report Covers Comprehensive Analysis on:

  • Market Segmentation and Regional Analysis
  • 10 year market size
  • Price analysis
  • Supply and demand analysis
  • Product life cycle analysis
  • Porter’s Five Forces and Value Chain Analysis
  • Analysis of developed and emerging economies
  • PEST analysis
  • Factor analysis of the market and forecasts
  • Opportunities, risks and market trends
  • Conclusion and recommendation
  • Regulatory landscape
  • Patent Analysis
  • Competition landscape
  • More than 15 company profiles

Regional Analysis For Liver Health Supplements Market Includes:

  • North America (United States, Canada, Mexico)
  • South America (Brazil, Argentina, Colombia, Peru, Rest of Latin America)
  • Europe (Germany, Italy, France, United Kingdom, Spain, Poland, Russia, Slovenia, Slovakia, Hungary, Czech Republic, Belgium, Netherlands, Norway, Sweden, Denmark, Rest of Europe)
  • Asia-Pacific (China, Japan, India, South Korea, Indonesia, Malaysia, Thailand, Vietnam, Myanmar, Cambodia, Philippines, Singapore, Australia and New Zealand, Rest of Asia-Pacific)
  • The Middle East and Africa (Saudi Arabia, United Arab Emirates, South Africa, North Africa, Rest of MEA

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Liver Health Supplements Market: Target Audience

  • Liver Health Supplement Service Providers
  • Hospitals and diagnostic laboratories
  • Drug discovery and development research centers
  • Investors and trading experts
  • Manufacturers, Distributors and Healthcare Providers
  • Trade publications and magazines
  • Government authorities, associations and organizations

About Us:

Market Group Statsville (MSG) partners with businesses and society to address their critical risks and challenges in order to seize the enormous opportunities that lie ahead. MSG began its work in 2017, and since then the brand has evolved to become a pioneer in business consulting and market research services.

We are the leading market research and strategy builder with the depth and breadth of solutions that perfectly meet all your needs. MSG provides solutions across a wide range of industry verticals in market sizing, analytics and incisive business intelligence. MSG’s experienced research analysts are skilled at digging deep and providing a variety of customizable data that helps you make decisions with clarity, confidence, and impact.

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If You Notice This On Your Body, Get Your Skin Checked – Eat This, Not That https://rogalevich.org/if-you-notice-this-on-your-body-get-your-skin-checked-eat-this-not-that/ Sat, 12 Mar 2022 17:01:46 +0000 https://rogalevich.org/if-you-notice-this-on-your-body-get-your-skin-checked-eat-this-not-that/ Although skin cancer can be prevented by taking preventative measures such as wearing protective clothing, sunglasses and sunscreen, it is still the most common cancer. According to Association of the American Academy of Dermatology, “about 9,500 people in the United States are diagnosed with skin cancer every day.” Dr. Ronald Tang, hematologist/oncologist and medical director […]]]>

Although skin cancer can be prevented by taking preventative measures such as wearing protective clothing, sunglasses and sunscreen, it is still the most common cancer. According to Association of the American Academy of Dermatology, “about 9,500 people in the United States are diagnosed with skin cancer every day.” Dr. Ronald Tang, hematologist/oncologist and medical director with Dignity Health Dorothy Leavey Cancer Center in Northridge, CA says Eat this, not that! Health, “The skin is your body’s largest organ, and irregularities in your skin can be a window into a person’s overall well-being. Skin cancer is the most common cancer in the United States and current estimates are 1 in 5 Americans will develop skin cancer during their lifetime according to the American Academy of Dermatology.Learning the ABCDEs of skin cancer is important for identifying, treating and preventing skin cancer. In addition, our skin can warn us of other serious health issues like liver and heart failure. Read the signs below to watch and for and to ensure your health and the health of others, don’t miss them. Sure signs you’ve already had COVID.

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Dr. Michael Hirt, a board-certified Harvard University nutritionist and board-certified in internal medicine and fellow at the Center for Integrative Medicine in Tarzana, California, says, “Platelets are microscopic spheres that contain naturally occurring molecules necessary for blood clotting and blood repair. cut paper that begins to bleed, your blood platelets stick to the edges of the wound and form a spider’s web of proteins that trap red blood cells to form a clot that acts as a plug to stop bleeding. just keep oozing blood all day. Petechiae are small, precise red marks that usually form in clusters when tiny blood vessels (called capillaries) break under the skin and begin to bleed. If you don’t have enough platelets to stop the bleeding, this rash can appear anywhere on the skin surface of the body, but it’s most commonly seen on the lower legs. anch when pressed and the petechiae do not itch or hurt. Once you see petechiae on your skin, your platelet count may be dangerously low and requires urgent evaluation by a medical professional.”

Patient with jaundice with yellowish discoloration of the skin compared to normal skin color.
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Dr. Tang reminds us, “The color of your skin is also important, and discoloration can provide clues to the health of other organs. Tanning of the skin may indicate problems with iron metabolism, especially in diabetic patients. heart failure. Yellowing of the skin, also known as jaundice, can signal liver failure or an acute liver infection such as hepatitis.

mole
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Dr Tang says: “If you notice a mole or spot on your skin that has asymmetry, uneven borders, dark black or multiple colors, larger than 6mm in diameter, or rapidly changing in size and of form, see your doctor immediately for a skin exam. These are early signs of skin cancer and recognizing them can save your life. I have personally seen many unfortunate individuals eliminate early signs of skin cancer and postponing doctor visits due to the COVID-19 pandemic. This has caused an increase in the number of patients being diagnosed with cancer at a later stage resulting in increased morbidity and mortality.”

dermatologist examining mole on back of male patient in clinic
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Dr. Enrizza P. Factor, clinical dermatologist and researcher with ThanksSkin explains: “Skin cancer is an abnormal growth of skin cells. It usually grows in areas exposed to the sun, but it can also form in places that are not normally exposed to the sun. The two main categories of skin cancers are defined by the cells involved.”

Woman enjoying the sun in the park
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Dr Factor says: “The first category includes basal cell and squamous cell skin cancers. These are the most common forms of skin cancer. They are more likely to develop on areas of your body that receive the most sun, such as your head and neck. They are less likely than other forms of skin cancer to spread and be life-threatening. But if left untreated, they can get bigger and spread to other parts of your body.

A woman in her thirties sits by her living room window with a cup of tea and gazes contemplatively.  She is a cancer survivor and wears a headscarf.
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“The second category of skin cancer is melanoma,” says Dr. Factor. “This type of cancer develops from cells that give your skin color. These cells are called melanocytes. Benign moles formed by melanocytes can become cancerous. They can develop anywhere on your body. In men, these moles are more likely to develop on the chest and back In women, these moles are more likely to develop on the legs Most melanomas can be cured if they are are identified and treated early. If left untreated, they can spread to other parts of your body and become more difficult to treat. Melanomas are more likely to spread than basal cell and squamous cell cancers of the skin.”

RELATED: The symptoms of COVID that doctors are most worried about

patient consulting with doctor on tablet
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According to Dr. Factor, “There are two main types of skin masses, keratinocytic carcinoma and melanoma. However, several other skin lesions are considered part of a larger umbrella of skin cancer. Not all are skin cancers, but they can become cancerous.

– Actinic keratosis: These red or pink patches of skin are not cancerous, but they are considered a form of precancer. If left untreated, these skin masses can develop into squamous cell carcinoma.

– Basal cell carcinoma: The most common form of skin cancer, basal cell carcinomas account for 90% of all cases of skin cancer. These are slow-growing lumps that most often appear on the head or neck.

– Squamous cell carcinoma: This type of skin cancer develops in the outer layers of the skin and is generally more aggressive than basal cell carcinoma. It may appear as red, scaly lesions on your skin.

– Melanoma: This type of skin cancer is less common, but it is the most dangerous type of skin cancer. In fact, melanoma accounts for only one percent of skin cancers, yet it causes the majority of skin cancer-related deaths each year. Melanoma forms in melanocytes, the skin cells that create pigment.”

RELATED: How long do COVID symptoms last?

close-up of doctors hands checking mans moles
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Dr Factor explains: “Skin cancers are not all the same and may not cause many symptoms. However, unusual changes in your skin can be a warning sign of different types of cancer. Being alert to changes on your skin can help you get diagnosed sooner.

Pay attention to symptoms, including:

  • Skin lesions: A new mole, unusual growth, bump, sore, scaly patch, or dark patch develops and does not go away.
  • Asymmetry: The two halves of the lesion or mole are not equal or identical.
  • Border: lesions have jagged, jagged edges.
  • Color: The spot has an unusual color, such as white, pink, black, blue, or red.
  • Diameter: The spot is larger than a quarter inch, or about the size of a pencil eraser.
  • Evolutionary: you can detect that the mole changes size, color or shape.”

RELATED: If you notice this on your body, get your arms checked.

Solar cream
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Dr Factor says: “Both types of skin cancer occur when mutations develop in the DNA of your skin cells. These mutations cause skin cells to grow out of control and form a mass of cancerous cells. Basal cell skin cancer is caused by ultraviolet (UV) rays from the sun or tanning beds. UV rays can damage the DNA inside your skin cells, causing unusual cell growth. Squamous cell skin cancer is also caused by UV exposure. Squamous cell skin cancer can also develop after long-term exposure to cancer. – causing chemicals. It can develop inside a burn scar or ulcer, and can also be caused by certain types of human papillomavirus (HPV). The cause of melanoma is unclear. Most moles don’t turn into melanomas, and researchers don’t know that. I don’t know why some people do it. Like basal cell and squamous skin cancers, melanoma can be caused by UV rays. But melanomas can develop in parts of your body that aren’t usually exposed to sunlight.

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Multivariate adjusted trends in adult alcoholic liver disease mortality in the United States, 1999–2017 https://rogalevich.org/multivariate-adjusted-trends-in-adult-alcoholic-liver-disease-mortality-in-the-united-states-1999-2017/ Fri, 11 Mar 2022 06:00:00 +0000 https://rogalevich.org/multivariate-adjusted-trends-in-adult-alcoholic-liver-disease-mortality-in-the-united-states-1999-2017/ Am J Transl Res. 2022 Feb 15;14(2):1092-1099. eCollection 2022. ABSTRACT OBJECTIVE: Trends in alcoholic liver disease (ALD) mortality have recently increased and differ according to various factors in the United States. However, these trends have only been analyzed using univariate models and, in fact, they can be influenced by various factors. We therefore examined trends […]]]>

Am J Transl Res. 2022 Feb 15;14(2):1092-1099. eCollection 2022.

ABSTRACT

OBJECTIVE: Trends in alcoholic liver disease (ALD) mortality have recently increased and differ according to various factors in the United States. However, these trends have only been analyzed using univariate models and, in fact, they can be influenced by various factors. We therefore examined trends in age-standardized mortality from ALD among US adults for the period 1999-2017, using piecewise multivariate log-linear models.

METHODS: We collected mortality data from the Centers for Disease Control and Prevention’s Large Scale Epidemiological Research Online Database, using the underlying cause of death.

RESULTS: We identified 296,194 ALD deaths and 346,386 deaths indirectly attributable to ALD during the period 1999-2017. ALD mortality adjusted for several variables and standardized according to age was stable between 1999 and 2006 (annual variation in percentage [APC]=-2.24, P=0.24), and increased between 2006 and 2017 (APC=3.18, P<0.006). Their trends did not differ by sex, race, age, or urbanization. Subgroup analyzes revealed upward-adjusted mortality trends for multiple variables and age-standardized in alcoholic fatty liver disease (APC=4.64, P<0.001), alcoholic hepatitis (APC=4 .38, P<0.001) and alcoholic cirrhosis (APC=5.33, P<0.001), but a decreasing trend in mortality in alcoholic liver failure (APC=-1.63, P=0.006) and unspecified ALD (APC=-0.86, P=0.013). Strikingly, non-alcoholic cirrhosis also had an increasing trend in multivariate-adjusted, age-standardized mortality (APC=0.69, P=0.046). In contrast, recent mortality trends were stable for all causes of death (APC=-0.39, P=0.379) and decreasing for malignancies excluding liver cancer (APC=-2 .82, P<0.001), infections (APC=-2.60, P<0.001), cardiovascular diseases (APC=-0.69, P=0.044) and respiratory diseases (APC=-0.56, P=0.002). Adjusted mortality with ALD as a contributing cause of death also had an increasing trend between 2000 and 2017 (APC = 5.47, P < 0.001). Strikingly, common comorbidities of ALD, including hepatocellular carcinoma, ischemic heart and cerebrovascular cardiovascular disease, and sepsis, have had increasing trends over the past 14-16 years.

CONCLUSIONS: ALD exhibited an increasing trend in multivariate-adjusted, age-standardized mortality among US adults, with no significant differences by gender, race, age, or urbanization. Three ALD subtypes (alcoholic fatty liver disease, alcoholic hepatitis, and alcoholic cirrhosis) and non-alcoholic cirrhosis had increasing mortality trends, while other ALD subtypes and other causes of death did not.

PMID:35273712 | CPM:PMC8902556

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This Is What Liver Cancer Looks Like, Doctors Say – Eat This, Not That https://rogalevich.org/this-is-what-liver-cancer-looks-like-doctors-say-eat-this-not-that/ Thu, 10 Mar 2022 14:15:23 +0000 https://rogalevich.org/this-is-what-liver-cancer-looks-like-doctors-say-eat-this-not-that/ According to the CDC, liver cancer kills 18,600 men and 9,000 women in the United States each year. Although the early stages of liver cancer usually have few symptoms, there are some warning signs of liver cancer that you should never ignore. “In its early stages, liver cancer may have no visible or felt symptoms. […]]]>

According to the CDC, liver cancer kills 18,600 men and 9,000 women in the United States each year. Although the early stages of liver cancer usually have few symptoms, there are some warning signs of liver cancer that you should never ignore. “In its early stages, liver cancer may have no visible or felt symptoms. However, as the cancer grows, people may notice one or more of these common symptoms. It is important to remember that these symptoms can also be caused by other health conditions. If you have any of these symptoms, talk to your doctor,” explains the CDC. Read on and to ensure your health and the health of others, don’t miss these Sure signs you’ve already had COVID.

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“Because the liver plays such a key role in the digestive system, cirrhosis and liver cancer can both cause you to lose your appetite and cause you to lose weight,” explains the NSW Cancer Council. “Chemotherapy, radiation and other cancer treatments can also have an impact, especially if you experience side effects such as nausea and vomiting, mouth ulcers and changes in taste and smell.”

Patient with jaundice with yellowish discoloration of the skin compared to normal skin color.
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Jaundice is yellowing of the skin and eyes resulting from excess bilirubin in the blood, due to obstruction of the bile ducts connecting the pancreas to the liver. “It’s one of the first symptoms a patient may notice,” says Jason A. Castellanos, MD, MS, a surgical oncologist at Fox Chase Cancer Center. “The bottom line is that identifying the cause of jaundice early is crucial.”

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woman in jeans jacket and pants itchy arm
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Itchy skin – or pruritus – is often linked to jaundice and a common symptom of liver cancer. “Pruritus is a common comorbidity in chronic liver disease and kidney disease,” according to an article published in the journal Scientific reports. “These patients frequently complain of pruritus despite the absence of rash or skin signs. Patients with chronic liver disease develop systemic itching that significantly impairs activity and sleep. Often this is not not relieved by scratching the itchy areas of the skin. Patients with primary biliary cholangitis (PBC) frequently experience pruritus in chronic liver disease.”

RELATED: Here’s how to feel like you’re 20 again, doctors say

young woman with nausea in denim outfit sitting on the bed
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Nausea is frequently linked to liver cancer, usually in association with other symptoms. “Symptoms of liver cancer may differ slightly, depending on the type of tumor you have,” explains Stanford Healthcare. “Please remember that other conditions can cause similar symptoms, so it’s important to see an experienced doctor for an accurate diagnosis.”

RELATED: Most People Get Belly Fat This Way, Experts Say

Young woman suffering from pain in bedroom
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Abdominal pain – or constant right shoulder pain – could be a symptom of liver cancer. “You should never ignore liver pain,” warns Carolina Digestive Health Associates. “It’s not something that has a benign cause, like stomach cramps when you have the stomach flu or a headache when you have a cold. If you have distinct pain in the liver area, you should see a doctor immediately.”

RELATED: Dr. Fauci just gave this essential virus update

Portrait of confident doctor in private clinic
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If you have any or all of these symptoms, talk to your healthcare provider as soon as possible to rule out any potential problems. Also, in general, the CDC says:

  • “Drink alcohol in moderation, if at all. If you choose to drink alcohol, limit the amount you drink. For women, that means no more than one drink a day. For men, that means no more than two drinks a day.
  • Maintain a healthy weight. If your current weight is healthy, try to maintain it by choosing a healthy diet and exercising most days of the week. If you need to lose weight, reduce the number of calories you eat each day and increase the amount of exercise you do. Try to lose weight slowly – 1 or 2 pounds (0.5 to 1 kilogram) every week.”
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Positive results in the early detection of liver cancer https://rogalevich.org/positive-results-in-the-early-detection-of-liver-cancer/ Tue, 08 Mar 2022 02:21:21 +0000 https://rogalevich.org/positive-results-in-the-early-detection-of-liver-cancer/ Helio Health, an AI-driven healthcare company focused on commercializing tests for early detection of cancer from a simple blood draw, today announced that Hepatology Communications has released positive results from the ENCORE study validating the strong clinical performance of HelioLiver in detecting the presence of early hepatocellular carcinoma (HCC), the most common form of liver […]]]>

Helio Health, an AI-driven healthcare company focused on commercializing tests for early detection of cancer from a simple blood draw, today announced that Hepatology Communications has released positive results from the ENCORE study validating the strong clinical performance of HelioLiver in detecting the presence of early hepatocellular carcinoma (HCC), the most common form of liver cancer and the seventh most common cancer in the world, but the second in terms of cancer-related mortality, often due to late diagnosis.1 In this prospective, multicenter, blinded phase 2 study, HelioLiver demonstrated high specificity %) and high sensitivity (76%) in detecting the Early-stage HCC (stage I and II), significantly outperforming other clinically available detection tools such as AFP (57%), GALAD (65%) and ultrasound (47%). 2,3 Considering HCC as a whole, HelioLiver performed at 85% sensitivity with the same specificity of 91%.2

Diagnostic tests for HCC Early Stage Susceptibility (I + II) Overall Sensitivity
HelioLiver2 76% 85%
PFA (≥ 20 ng/mL)2 57% 62%
GALAD score (≥ -0.63)2 65% 75%
Ultrasound3 47% 84%
Note: Table shows HelioLiver sensitivities at 91% specificity2
2 Lin N, et al. 2021.
3 Tzartzeva K, et al. 2018.

Helio has developed its next-generation sequencing platform, ECLIPSETM, to identify 77 methylation targets across 28 genes. These DNA markers work in combination with serum HCC proteins AFP, AFP-L3% and DCP to enhance the multi-analyte algorithm.

• The area under receiver operating characteristic (AUROC) for HelioLiver was 0.944, demonstrating significantly better predictive ability than the other tests.

• At a fixed specificity of 87.5%, HelioLiver achieved 87% sensitivity for early stage HCC and 90% overall sensitivity.

• 10 of the 28 genes used in the HelioLiver assay were found to be directly involved in molecular pathways known to be involved in the pathogenesis of HCC while only one of the 497 genes studied but not selected met the same criteria, suggesting that the markers in HelioLiver are more biologically relevant than tests that use these other genes.

Hepatology Communications is the official open access, peer-reviewed journal of the American Association for the Study of Liver Diseases (AASLD), dedicated to the rapid dissemination of high-quality research in hepatology. AASLD is the most respected medical guidelines organization for liver disease in the United States.

HelioLiver is being further evaluated in Helio’s prospective pivotal biomarker study, CLiMB (NCT03694600), where test performance will be directly compared to ultrasound using multiphasic MRI as the standard of care for the diagnosis of HCC.

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Supporting the 3rd leading cause of cancer-related death https://rogalevich.org/supporting-the-3rd-leading-cause-of-cancer-related-death/ Mon, 07 Mar 2022 15:18:52 +0000 https://rogalevich.org/supporting-the-3rd-leading-cause-of-cancer-related-death/ Liver cancer is the third leading cause of cancer-related death worldwide, and the incidence of primary liver cancer in the United States has tripled over the past four decades. While chronic viral hepatitis is the primary route to liver cancer in the United States, non-infectious causes such as morbid obesity, type 2 diabetes, non-alcoholic fatty […]]]>

Liver cancer is the third leading cause of cancer-related death worldwide, and the incidence of primary liver cancer in the United States has tripled over the past four decades. While chronic viral hepatitis is the primary route to liver cancer in the United States, non-infectious causes such as morbid obesity, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and non-infectious steatohepatitis associated alcoholism (NASH) increased rapidly. We will describe each of these pathways, starting with viral hepatitis (HCV and HBV) and alcoholic cirrhosis.


There is a morbid saying that cancer eventually affects us all, unless something else affects us first.

While some cancers currently have no accessible prevention, some can be effectively prevented. Hepatocellular carcinoma (HCC) is one of those that can be prevented, but once HCC is established and symptomatic, survival rates drop sharply. While liver cancer is the 8and location of cancer site by prevalence (Figure 1), this is the 3rd leading cause of death (Figure 2). HCC has a high mortality profile with a median survival after diagnosis of 6-20 months, and in the United States it has a 5-year survival rate of only 10% (Golabi, et al., 2017)

Figure 1. Top 10 cancer sites by case (Sung et al, 2021)

Top 10 cancer sites by death

Figure 2. Top 10 cancer sites by death (Sung et al, 2021)

The COVID-19 pandemic has rightly occupied the minds and efforts of nearly everyone in healthcare for the past two years, but HCC has not gone away and continues to cause daily damage. . HCC was on 4and leading cause of cancer-related death in 2019 (Yang et al., 2019), and has been steadily increasing – it has tripled in the United States (Rawla, Sunkara, Muralidharan & Raj, 2018).

Although your daily chance of encountering a patient with HCC is still small, it increases year by year and there is a serious risk of missing the window of opportunity to prevent full-blown HCC.

This blog will describe how to be alert to the causes and cases of HCC, and we will provide you with tools and resources to help you identify HCC, ways to connect your patient with appropriate specialists, and help you find appropriate studies and trials for your patient.

There are four main HCC risk factors:

  1. Hepatitis B (HBV)
  2. Hepatitis C (HCV)
  3. Excessive consumption of alcohol
  4. Non-alcoholic fatty liver disease (NAFLD) resulting in non-alcoholic steatohepatitis (NASH)

How likely are you to encounter hepatocellular carcinoma in patients?

In the near future, it is unlikely that any specific patient you see will already have HCC. That’s great, but it’s also a problem because you’re less likely to recognize it immediately. For HCC, delay is the killer.

However, you are very likely to see a patient who, regardless of their primary complaint, is already on one or more of the four main HCC pathways. The picture is also skewed when race is taken into account – while the overall rate of HBV infection has declined significantly since 1991, it remains a concern for the African American population. In 2017, non-Hispanic African Americans were 1.5 times more likely to die from viral hepatitis than whites, and almost twice as likely to die from HCV. (HHS-OMH”Hepatitis and African Americans”)

Anything you can do to increase HBV vaccination rates and prevent HCV infection will help steer your patients away from the viral pathway. It is therefore important to use screening tests for HBV and HCV and to strongly encourage HBV vaccination even if patients are not in high-risk categories. Likewise, addressing alcohol use and encouraging your patients to follow guidelines will help steer them away from alcohol’s path to HCC.

the NAFLD/NASH pathway talks about lifestyle changes that are inherently healthier and worth discussing. Discussing healthy eating, limiting portion sizes, and maintaining a healthy weight with your patients can help steer them away from this path.

Patient history that should raise your index of suspicion includes past unprotected sex, use of needles, binge drinking or binge drinking, or increasing obesity. However, it is important to keep in mind that many patients who had no obvious risk factors in their history nevertheless went on to have HCC. Although atypical, HCC can be the result of maternal HBV infection or HCV transmitted to children. For an example, see “Better off bald: a life in 147 days

How to discuss staging with patients

Discussing staging with patients can be difficult, and the literature is often either aimed at clinicians or contains misleading information. Blue Faery provides clinically accurate yet understandable materials to help you describe the staging and help the patient understand where they are on the spectrum.

These materials include:

  • The HCC patient education brochures is written in plain language and intended to be read by the patient.
  • The Blue Faery and Exelixis staging discussion pad contains anatomical graphics and easy-to-understand text. Each double-sided sheet allows the doctor to add notes that his patient can use after the appointment.
  • the Liver Cancer Patient Resource Guide is a 20-page booklet containing relevant explanations and resources for HCC patients and their caregivers.

Blue Faery will send these documents free of charge to any doctor who requests them.

How to Find Hepatocellular Carcinoma Specialists, Treatment Options and Clinical Trials

Treatment of HCC is best approached with a multidisciplinary team coordinated by a primary care physician. The most effective approach will likely require the expertise of multiple healthcare professionals, including the primary care physician, and may include an oncologist with experience in HCC, gastroenterologist, hepatologist, radiologist interventionist, a radiation oncologist, a surgical oncologist and a transplant surgeon.

Where to find clinical trials specific to hepatocellular carcinoma

To find all clinical trials, the best option is clinicaltrials.gov, but this website can be confusing and difficult to navigate. To help physicians guide their patients to relevant trials, Blue Faery has a custom HCC clinical trial browser.

Where can patients find community support?

Patient communities are very helpful in providing patients with practical guidance for their care journey and are often a source of emotional support from people who understand the experience.

the Blue Fairy Liver Cancer Community is a free, HIPAA-compliant online community where patients and caregivers are invited to join and seek or exchange relevant information about HCC care. Members ask questions, discuss concerns and find common ground along their cancer journey. Forum moderators include Community Ambassadors who were former caregivers of HCC patients.

For individual patient support, Blue Faery has partnered with Imerman Angels, a non-profit organization that provides peer-to-peer support services to the liver cancer community. Blue Faery and Imerman Angels believe that no one should face cancer alone.

Conclusion

With proper screening, testing and inoculation, the viral pathway to HCC can often be interrupted. Blue Faery provides free, patient-readable and clinically accurate materials to help physicians discuss their patients’ staging, options and resources.

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For cancer patients on immunotherapy, harmful gut bacteria may be more important than helpful bacteria https://rogalevich.org/for-cancer-patients-on-immunotherapy-harmful-gut-bacteria-may-be-more-important-than-helpful-bacteria/ Tue, 01 Mar 2022 03:34:13 +0000 https://rogalevich.org/for-cancer-patients-on-immunotherapy-harmful-gut-bacteria-may-be-more-important-than-helpful-bacteria/ Melanoma patients receiving therapy that helps their immune system kill cancer cells respond differently to treatment depending on the types of microbes in their gut, and new research suggests microorganisms that interfere with therapy have more influence than the beneficial ones. The results of a collaboration that included researchers from Oregon State University, the National […]]]>

Melanoma patients receiving therapy that helps their immune system kill cancer cells respond differently to treatment depending on the types of microbes in their gut, and new research suggests microorganisms that interfere with therapy have more influence than the beneficial ones.

The results of a collaboration that included researchers from Oregon State University, the National Cancer Institute, the Frederick National Laboratory for Cancer Research and the University of Pittsburgh were published today in natural medicine.

The research is a key step in the fight against several types of cancer, including melanoma, the deadliest form of skin cancer, said Andrey Morgun of the OSU College of Pharmacy.

“Our findings shed new light on the very complicated interplay between the gut microbiome and the immunotherapeutic response in cancer and pave the way for future studies,” he said.

Nationally, melanoma is the fifth most common cancer. About 100,000 new cases of melanoma will be diagnosed in the United States in the coming year, and more than 7,000 of those patients are expected to die, according to the American Cancer Society.

One of the most aggressive cancers, melanoma kills by metastasizing or spreading to other organs such as the liver, lungs and brain.

The new study involves a therapeutic technique called immune checkpoint blockade, often referred to by its initials ICB, which has revolutionized the treatment of melanoma and cancer in general.

ICB therapy relies on inhibitor drugs that block proteins called checkpoints that are produced by certain cells of the immune system – T cells, for example – and also by certain cancer cells.

Checkpoints help prevent immune responses from being too strong, but sometimes that means preventing T cells from killing cancer cells. So when checkpoints are blocked, T cells can kill cancer cells better.

ICB has been a game-changer in cancer treatment, Morgun said, and several studies have shown that patients’ gut microbes play a role in a patient’s response. The human gut microbiome is a complex community of over 10 trillion microbial cells representing approximately 1,000 different bacterial species.

Morgun and colleagues looked at data from several cohorts of melanoma patients receiving a type of CVI known as anti-programmed cell death protein therapy, abbreviated as anti-PD-1 therapy.

Among other methods, they used a computer modeling technique, cross-realm network analysis, invented by Morgun and Natalia Shulzhenko of Oregon State’s Carlson College of Veterinary Medicine, to determine which bacteria were associated with responses better or worse to treatment.

“We established several microbiotypes and some of them were clearly correlated with response to cancer immunotherapy,” Morgun said. “Two microbial signatures – one relatively heavy with Lachnospiraceae species, the other relatively heavy with Streptococcaceae species – were related to favorable and unfavorable clinical response, respectively.”

The results also suggest that approximately one year after the start of treatment, the gut microbiota becomes a dominant factor in response to treatment, and that treatment-impairing microbes appear to play a more important role than treatment-enhancing ones, a- he added.

Amiran Dzutsev and Giorgio Trinchieri of the National Cancer Institute and Hassane Zarour of the University of Pittsburgh are corresponding authors of the study, which was supported by the National Institutes of Health and the National Cancer Institute.

Source of the story:

Material provided by Oregon State University. Original written by Steve Lundeberg. Note: Content may be edited for style and length.

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What is a payday loan? https://rogalevich.org/what-is-a-payday-loan/ Fri, 25 Feb 2022 22:26:00 +0000 https://rogalevich.org/what-is-a-payday-loan/ What is a payday loan? payday ready are generally short-term unsecured loans characterized by high interest rates that generally do not require a credit check. Although there is no exact and universal definition of the term, the US Consumer Financial Protection Bureau indicates that this type of loan is usually $500 or less and is […]]]>

payday ready are generally short-term unsecured loans characterized by high interest rates that generally do not require a credit check.

Although there is no exact and universal definition of the term, the US Consumer Financial Protection Bureau indicates that this type of loan is usually $500 or less and is usually due on the borrower’s next payday. States have different laws governing these types of fast loans, but they may be available to Americans through in-store payday lenders or in line, depending on location. The due date on payday loans is generally two to four weeks from the date of issuance, and lenders generally do not consider borrowers’ credit scores or their ability to meet other financial obligations when approving the loan.

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To secure a payday loan, payday lenders often require a personal check from the borrower for the loan amount, plus interest and fees, for a future deposit. They often require direct access to the borrower’s bank account.

Payday lenders hold the personal check until the borrower receives their next paycheck, direct deposit or social Security Payment. Depending on the terms of the loan and the laws of the state in question, some payday lenders offer long-term repayment plans that allow them to make multiple electronic withdrawals from the borrower’s bank account.

The average term for payday loans is about two weeks, and loans typically range between $50 and $1,000. In exchange for quick loans that don’t require a credit check, payday borrowers typically pay exorbitant interest rates and fees on their loans. Payday lenders often charge annual percentage ratesor APR, of 400% or more on their loans, plus finance charges of between $10 and $30 for every $100 borrowed.

The only requirements to qualify for most payday loans are an opening Bank account relatively in good standing, a regular income and a source of identification.

Because little consideration is given to the financial status or creditworthiness of borrowers, the CFPB has found that payday loans have a high default rate of around 20%. Additionally, approximately 80% of payday borrowers renew or re-borrow their loans within 30 days of their initial loan.

Qualified state borrowers can apply for a payday loan online from companies such as MoneyMutual, CashUSA.com, and BillsHappen. Many payday lenders also have thousands of physical stores in the United States.

In times of financial emergency or life or death situation, payday loans may be one of the only places Americans have bad credit can turn to temporary financial assistance. However, due to widespread deception and predatory behavior in the payday loan industry, the CFPB, Federal Trade Commission, and other federal and state regulators have repeatedly warned Americans of the dangers of payday lending. payday and imposed restrictions on the activities of payday lenders.

A 2016 five-year study by Pew Charitable Trusts found that 12 million Americans take out payday loans each year, and those borrowers collectively pay $9 billion a year in loan fees alone.

  • Speed. Payday loans are fast, and lenders often approve the same or next day.
  • Ease of use. It’s usually easy to get approved for a payday loan as long as the applicant has a stable source of income, a bank account in good standing, and proper identification. Borrowers can even get payday loan approval online. While some critics say payday loans are inherently predatory, there are laws in place to protect the rights of borrowers.
  • Availablity. Depending on the situation, payday loans may be one of the only viable sources of emergency cash for borrowers with bad credit.

  • High cost. Payday loans can come with annual interest rates of 400% or more, and finance charges can be 15% to 30% of the loan amount. These high interest rates stand out even more compared to the national average of around 16.17% credit card interest rate or the average interest rate of 4.25% over 30 years mortgage end of February 2022.
  • Debt cycle. Due to interest and fees, a payday loan can easily force the borrower to put off the majority of their next paycheck, creating an opportunity for borrowers to fall into a cycle of repeat loans.
  • Harassment. Payday lenders have a reputation for exploiting financially vulnerable borrowers and using aggressive and harassing collection practices.

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Oregon man diagnosed with ‘terminal’ liver cancer continues to thrive https://rogalevich.org/oregon-man-diagnosed-with-terminal-liver-cancer-continues-to-thrive/ Thu, 24 Feb 2022 18:48:22 +0000 https://rogalevich.org/oregon-man-diagnosed-with-terminal-liver-cancer-continues-to-thrive/ Understanding liver cancer and the importance of second opinions Larry Sullivan was diagnosed with ‘terminal’ liver cancer in 2019. But now, thanks to an individualized treatment approach curated by multiple doctors, he feels better than he has in a long time, with his cancer nearly having faded away. Liver cancer begins in the liver, an […]]]>

Understanding liver cancer and the importance of second opinions

  • Larry Sullivan was diagnosed with ‘terminal’ liver cancer in 2019. But now, thanks to an individualized treatment approach curated by multiple doctors, he feels better than he has in a long time, with his cancer nearly having faded away.
  • Liver cancer begins in the liver, an organ located below the diaphragm and above the stomach. The most common form of the disease is hepatocellular carcinoma, but there are also other types of liver cancers.
  • One of the greatest cancer researchers of our time told SurvivorNet that people should get “multiple” opinions after a cancer diagnosis.

When Larry Sullivan was diagnosed with “terminal” liver cancer in 2019, his mind started racing. But thanks to an individualized treatment approach from multiple doctors, Sullivan’s cancer is almost gone today.

“It’s so amazing and unexpected for me,” he said where he is today. “It’s been a tough trip but I’m doing great.”

With the help of Oregon Cancer Alliance which strives to bring together leading cancer specialists to provide coordinated expert care, Sullivan received a treatment plan organized by several specialists from different clinics. To begin with, Sullivan underwent radioembolization. This procedure involves injecting small beads (called microspheres) with a radioactive isotope (yttrium-90 or Y-90) attached into the hepatic artery that supplies blood to the liver and gallbladder. Then the beads emit small amounts of radiation to the tumor site for several days.

“It allows us to go to where the tumors are and deliver treatment,” says the interventional radiologist, Dr. Donald Garbett, who performed the procedure. “By delivering the treatment directly into the tumour, the rest of the body doesn’t feel it as it would with other treatment procedures. We were able to treat all of Mr. Sullivan’s tumor and it immediately started to shrink.

From there, Sullivan was prescribed a combination of immunotherapy drugs, Yervoy and Opdivo, to treat the cancer that had spread to his lungs and bones. Immunotherapy, in general, has been shown to be extremely effective in treating several cancers, although it does not work for everyone.

Fighting cancer with the body’s own cells: the immunotherapy revolution

After this treatment, doctors could no longer see the cancer in Sullivan’s lungs and bones. In addition to these treatments, Sullivan also underwent spinal surgery and radiation therapy.

Now Sullivan is feeling well and is returning to work as a part-time school psychologist. He also spends time with his family, travels and even restores boats.

“I’m very lucky. I didn’t even imagine six months ago that this would happen. says Sullivan. “It’s been difficult at times, but now I can do things again and have a little joy in my life. am really excited to have more time with my family.

Understanding Liver Cancer

Liver cancer begins in the liver, an organ located below the diaphragm and above the stomach. American Cancer Society estimates that approximately 41,260 new cases (28,600 in men and 12,660 in women) of primary liver cancer and cancer of the intrahepatic bile ducts will be diagnosed in 2022. The most common form of the disease is hepatocellular carcinoma, but there are also other types of liver cancer.

Several risk factors may increase the risk of developing hepatocellular carcinoma (HCC), including but not limited to the following:

  • Gender (hepatocellular carcinoma is much more common in men than in women)
  • Race/ethnicity (In the United States, Asian Americans and Pacific Islanders have the highest rates of liver cancer, followed by Hispanics/Latinos, American Indians/Alaska Natives , African Americans and Whites)
  • Chronic viral hepatitis
  • Cirrhosis (a disease in which liver cells are damaged and replaced by scar tissue)
  • Excessive consumption of alcohol
  • Smoking
  • Obesity
  • Type 2 diabetes

Cancer survivor Joel Naftelberg learned to dance to his problems

Blood tests, ultrasounds, CT scans (x-ray images), MRIs (medical imaging), and angiograms are usually used to confirm a diagnosis of liver cancer. A liver biopsy, where a small piece of tissue is removed and analyzed for cancer cells, may also be performed.

Often a liver transplant is considered the best plan when the patient is eligible. For cases of recurrent liver cancer and cancer that has spread throughout the body, your doctor may consider targeted therapy, immunotherapy, or chemotherapy as the next step.

The importance of getting a second opinion

After you’ve been diagnosed with cancer, it’s important to remember that you can, and should, talk to other cancer specialists about your disease.

“If I had any advice for you following a cancer diagnosis, it would be to first seek several opinions on the best care”, National Cancer Institute Chief of Surgery Steven Rosenberg said SurvivorNet in a previous interview. “Because finding a doctor who is up to date with the latest information is important.”

RELATED: Second (and third) opinions are important when deciding between surgery or radiation therapy

As we highlight in several areas of SurvivorNet, highly respected doctors sometimes disagree about the right treatment, and advances in genetics and immunotherapy create new options. Moreover, in some cases, the specific treatment is not clearly defined. This is one more reason why it is crucial to understand the potential approaches to your disease.

At the National Cancer Institute, there is a patient referral service that “will guide patients to the right group based on their disease state so that they can access these experimental new treatments,” says Rosenberg.

Cancer research legend urges patients to get multiple opinions

Additionally, getting another opinion can also help you avoid doctor bias. For example, some surgeons have radiotherapy centers. “So there may be a conflict of interest if you go to a surgeon who recommends radiation therapy, because that type of facility is partly owned by that type of facility,” Dr. Jim Hudirector of robotic surgery at Weill Cornell Medical Center, tells SurvivorNet.

Other reasons to get a second opinion include:

  • To see a doctor who is more experienced in treating your type of cancer
  • You have a rare type of cancer
  • There are many ways to treat your cancer
  • You feel like your doctor isn’t listening to you or giving you good advice
  • You have trouble understanding your doctor
  • You do not like the treatment recommended by your doctor or are worried about its possible side effects
  • Your insurance company wants you to get another medical opinion
  • Your cancer is not getting better with your current treatment

Be Insistent, Be Your Own Advocate, Says Leading Expert

Ultimately, being proactive about your health could be a matter of life and death. Learn as much as you can from as many experts as you can, so you know you’ve done your best to take control of your health.

Contributor: Marisa Sullivan

Learn more about SurvivorNet’s rigorous medical review process.

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