What is Zantac and can it cause liver cancer?

A simple medicine to treat heartburn may be linked to cancer.

Zantac, a ranitidine drug, has garnered attention for all the wrong reasons. Problems with its makers began to escalate in late 2019 when several reports were linked to its likelihood of causing various types of cancer.

In this article, we will discuss what Zantac is and what it does, and talk about the possibility of Zantac users with bladder cancer Let’s dive into it.

What exactly is Zantac?

Since its release in the 1980s, Zantac has been consumed, marketed, and considered safe in the medical fraternity. Many people suffering from illnesses such as indigestion, heartburn, GERD (gastroesophageal reflux disease)and others have been using the drug for years or even decades to treat their symptoms.

Zantac (ranitidine) belongs to the histamine-2 blocker class of medications. It helps reduce the amount of acid produced by your gut. It has traditionally been used to treat and prevent intestinal and intestinal ulcers. It has also been used to treat Zollinger-Ellison syndrome, a disorder in which the stomach generates excessive amounts of acid.

Why was Zantac taken off the drug market?

When ranitidine is stored at extreme temperatures, contaminating carcinogenic NDMA present in many ranitidine drugs such as Zantac can accumulate in large quantities. These high amounts can be harmful to the user. There are limited studies on NDMA, but researchers are noticing some links to cancer in mouse models.

This led the FDA to order all manufacturers of ranitidine to remove the drug from the US market. The main reason for this is that using Zantac may increase your risk of cancer due to NDMA, as mentioned above.

Regular use of Zantac can lead to many types of cancer, including liver cancer. The assumption is that the drug is metabolized by the liver, which may lead to the formation of NDMA.

This NDMA can then be transported through the bloodstream. Since the generation of NDMA after taking Zantac (Ranitidine) can occur in multiple parts of the body, it may be linked to a variety of malignancies.

Not found by the FDA, but an online pharmacy

The problem of ranitidine-induced liver cancer and severe liver damage has not come to the attention of the FDA or the pharmaceutical companies. Instead, it was Valisure, an online pharmacy, that did the government service of informing the public of this important situation.

Valisure’s approach is to purchase pharmaceutical items and test them independently. The company is dedicated to public safety and has discovered contamination in several well-known pharmaceutical products.

Ranitidine contains NDMA

Just when word of the NDMA (N-Nitrosodimethylamine) contamination reached Valisure, pharmaceutical manufacturers and stores themselves reacted quickly. The drug companies that developed the cheap Zantac and ranitidine, according to lawsuits, had long known their drugs contained a cancer-causing chemical.

Liver cancer and Zantac

Liver cancer is defined as cancer that starts in the cells of your liver. The liver is a huge organ located in the upper right part of your belly, below the diaphragm and above the stomach.

Several malignant tumors can arise in the liver. Hepatocellular carcinoma is the most common type of liver cancer and it begins in the main type of liver cell called the hepatocyte. Hepatoblastoma and intrahepatic cholangiocarcinoma are two less common types of liver cancer. While in some cases, liver cancer is treatable, the mortality rate associated with the disease is alarming.

Currently, there is no way to know how likely you are to have liver damage after taking Zantac. However, there is some evidence that the NDMA in Zantac may increase the risk of developing liver problems.

If you or someone close to you has taken Zantac regularly for a medical condition and has had major liver problems, you may have the right to join a class action lawsuit against the makers of Zantac.

Zantac has been linked to a variety of cancers

People who have developed the following cancers as a result of persistent and prolonged use of Zantac or comparable ranitidine medicines may be eligible for compensation, in addition to liver cancer:

  • Bladder cancer is a type of cancer that affects the bladder
  • Stomach cancer
  • Esophageal and colon cancer
  • Kidney/kidney cancer
  • Leukemia
  • Multiple myeloma
  • Non-Hodgkin lymphoma
  • Pancreatic carcinoma is a type of cancer that affects the pancreas
  • Prostate cancer is a type of cancer that affects men
  • Small intestine cancer


Zantac is no longer available in the market due to various legal claims from cancer patients who were diagnosed as a result of its prolonged use. Just like many other cancer claims, the claims of Zantac causing liver cancer are not yet fully proven. But there are reported cases where regular use of Zantac has led to liver problems. Science will know more in the years to come.



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